Imputation by random draws from a manually defined distribution

manual_impute imputes missing values in a proteomics dataset by random draws from a manually defined distribution.

Usage

manual_impute(se, scale = 0.3, shift = 1.8)

se: SummarizedExperiment, Proteomics data (output from make_se() or make_se_parse()). It is adviced to first remove proteins with too many missing values using filter_se() and normalize the data using normalize_vsn().
scale: Numeric(1), Sets the width of the distribution relative to the standard deviation of the original distribution.
shift: Numeric(1), Sets the left-shift of the distribution (in standard deviations) from the median of the original distribution.

An imputed SummarizedExperiment object.